1,4-andro (1,4-androstadienediol)
or (1,4-androstadienedione)
Target Hormone: Boldenone (1-dihydrotestosterone)
Molecular name of target hormone: 1,4-androstadiene-3-one,17b-ol
Target conversion: moderate to high, estimated just over 10 %
Conversion enzyme: 17-hydroxysteroid dehydrogenase (17HSD)
DHT conversion: some conversion
Estrogenic effects: aromatisation of the prohormone
Definitely more promising than the 5-AA. I found it has great resemblance to
the 1AD in the fact that it has no estrogen aromatisation possibility, assures
almost all gains as dry weight and the double bond at the one position which
ensures greater oral activity without extra liver toxicity. However, Not here,
nor on the 5AA by the way, was there any kind of study attached showing the
efficacy of either product. It is touted as a precursor to boldenone, another
popular steroid and pre-contest hardening agent. In this case there is more
truth in it. Only that boldenone has a hydrogen and oxygen bonded and the 1,4-andro
has a double bonded oxygen atom. Boldenone becomes methandrostenolone in its
methylated form, also known as Dianabol, possibly the most popular oral steroid
in the world, ever.
If this was a diol version this could without a doubt surpass any prohormone
ever created, including 1AD. But its a dione version with inherent flaws. Im
also not convinced a diol version will ever come out. [Editors Note: A diol
version is now available. AndroPoise by SciFit contains 100mg.] Unlike 1AD which
was created in a lab as a dione, then perfected to a diol, 1,4-andro isnt made
by human hands but extracted from the feces of a cow. Cows are treated with
progesterone for various reasons, and under that circumstance they produce this
in their bowels it seems1. This is the result of that isolation. Its also the
topic of a hot debate of whether or not this is legal. In any case, 1,4-andro
can be considered the non-5-alpha reduced version of 1AD and a potent anabolic
precursor. However, it definitely leaves a lot of stacking options. Because
of the 1-double bond it has a high oral efficacy, meaning low doses can exert
an effect. So in a stack with another prohormone it may be able to rival the
effect of a mild steroid, but again youd have to be able to make it cost-effective
for it to rival 1AD.
One thing I particularly like about 1,4-andro is that despite the fact that
it can stimulate the androgen receptors and aromatize, it does both in such
a small amount that side-effects are nearly non-existant. Combined with high
oral efficacy it can easily match Nor-diol, perhaps even beat it, in the safety
department. It can also be a handy supplement for endurance athletes since it
stimulates Erythropoesis, the manufacture of red blood cells in the bone marrow
and releasing them in large quantities in the blood. Red blood cells carry oxygen
and this increases the capacity for strenuous and continual activity with a
lessened risk of cramps or musclular failure. This is also the result of the
hormone EPO (erythropoetin). Boldenone acts by increasing EPO release from the
kidneys. Much like doing a height-stage. EPO is also a heavily abused drug amongst
runners and cyclists. Another potent effect it may have is that despite slightly
aromatizing itself, it may act as aromatase inhibitor for other products in
several forms. One study showed this to be true for 1,4-androstadienedione2
whereas another shows the same for several metabolites3. That makes 1,4-andro
perfect for limiting estrogenic side-effects in a bulking stack as well.
In my opinion this shows a lot of promise, but Id like to see something as
far as a head to head study goes. However, if 1,4-andro tickles your fancy,
again ordering from Impact Nutrition, who has the patent, is and will remain
an expensive affair.
1 - Vadalkar K, Gupta FC, Bhat HK, Chopra CL., Indian J Exp Biol 1980 Mar;18(3):245-8
2 - Abul-Hajj YJ, Liu XP, Hedge M., Steroids 1995 May;60(5):423-7
3 - Numazawa M, Oshibe M, Yamaguchi S, Tachibana M., J Med Chem 1996 Mar 1;39(5):1033-8
Read the full article by Peter "Big Cat" Van Mol: Prohormone Science
- Revised with new info!